Please use this identifier to cite or link to this item:
Title: Corticosteroid physiology and principles of therapy.
Authors: Gupta, Priyanka
Bhatia, Vijayalakshmi
Issue Date: 19-Oct-2008
Citation: Gupta P, Bhatia V. Corticosteroid physiology and principles of therapy. Indian Journal of Pediatrics. 2008 Oct; 75(10): 1039-44
Abstract: The adrenal cortex secretes glucocorticoids (GC), mineralocorticoids (MC) and androgens. GC maintain homeostasis, MC regulate fluid and electrolyte balance and adrenal androgens contribute to development of secondary sexual characteristics. Pharmacologic GC therapy is frequently indicated in the pediatric age group. Besides having many important side effects, prolonged high dose systemic GC therapy has a suppressive effect on endogenous steroid production. Therefore, GC therapy should be withdrawn gradually and stopped based on assessment of hypothalamo-pituitary-adrenal (HPA) axis recovery. Patients with HPA axis suppression require physiological replacement of GC along with enhancement of doses during periods of stress. Due to its immunosuppressive effects, issues about safety and efficacy of live virus vaccines in patients receiving systemic high dose GC therapy must be borne in mind.
Appears in Collections:Indian Journal of Pediatrics

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.