Please use this identifier to cite or link to this item: http://imsear.hellis.org/handle/123456789/72662
Title: Role of bone marrow trephine biopsy in the diagnosis of marrow involvement in Hodgkin's disease.
Authors: Subramanian, Rajiv
Basu, Debdatta
Badhe, Bhawana
Dutta, Tarun K
Issue Date: 22-Jul-2007
Citation: Subramanian R, Basu D, Badhe B, Dutta TK. Role of bone marrow trephine biopsy in the diagnosis of marrow involvement in Hodgkin's disease. Indian Journal of Pathology & Microbiology. 2007 Jul; 50(3): 640-3
Abstract: Bone marrow involvement in Hodgkin's disease alters the stage and hence the prognosis and treatment modality. Seventy-six patients of biopsy proven Hodgkin's disease in whom a bone marrow aspiration and biopsy were done simultaneously at the time of diagnosis were included in the study. Bone marrow involvement was seen in 14 (18%) cases. All 14 cases were diagnosed on biopsy. Only one aspirate was suspicious of involvement. Rest was either diluted (28%) or was normal (64%). Eleven patients were upstaged from stage I, II and III to stage IV. All patients had cytopenia of one or more cell line. Increased fibrosis, necrosis and a polymorphic cellular infiltrate were associated findings in the marrow. We wish to highlight the importance of bone marrow trephine biopsy over aspirate in staging even clinically early stage Hodgkin's disease.
URI: http://imsear.hellis.org/handle/123456789/72662
Appears in Collections:Indian Journal of Pathology & Microbiology

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