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Title: Selenite cataract and its attenuation by vitamin E in Wistar rats.
Authors: Mathew, Joe Prasad
Thomas, V C
Thomas, Isaac
Issue Date: 2-Jun-2003
Citation: Mathew JP, Thomas VC, Thomas I. Selenite cataract and its attenuation by vitamin E in Wistar rats. Indian Journal of Ophthalmology. 2003 Jun; 51(2): 161-70
Abstract: PURPOSE: To study the role of vitamin E in preventing cataract formation in experimental animals. METHODS: An experimental model (selenite cataract) was selected for this study. Selenite cataract was produced in rats by subcutaneous administration of sodium selenite. Biochemical and histological changes following induction of selenite cataract in weanling Wistar rats were studied vis-a-vis the role of vitamin E in attenuating or preventing cataractogenesis. RESULTS: Vitamin E was capable of preventing selenite cataractogenesis. Selenite cataract did not develop in 91.6% (11 of 12) and 76.7% (8 of 12) vitamin E treated rats, when administered on the 12th and 10th post partum day respectively. CONCLUSION: The study confirmed that selenite induced cataract in Wistar rats is attenuated by vitamin E.
Appears in Collections:Indian Journal of Ophthalmology

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