Please use this identifier to cite or link to this item: http://imsear.hellis.org/handle/123456789/72096
Title: Introduction, mechanism of action and rationale for anti-vascular endothelial growth factor drugs in age-related macular degeneration.
Authors: Kim, Ramasamy
Issue Date: 24-Nov-2007
Citation: Kim R. Introduction, mechanism of action and rationale for anti-vascular endothelial growth factor drugs in age-related macular degeneration. Indian Journal of Ophthalmology. 2007 Nov-Dec; 55(6): 413-5
Abstract: Recent developments may provide an opportunity to improve outcome in individuals who develop neovascular age-related macular degeneration (ARMD). Several therapies have been introduced that show promise for halting the progression of this disorder. However, data from controlled clinical trials to test the relative efficacy of different management strategies across the subtypes of disease remain limited. New treatment modalities that target the neovascularization process, including leakage from choroidal neovascularization (CNV), are currently being developed. Vascular endothelial growth factor (VEGF) has been implicated as a key mediator in the pathogenesis of ARMD-related CNV. Anti-VEGF strategies show promise as potential therapeutic agents for the treatment of CNV and are currently undergoing active clinical investigation. Such strategies include anti-VEGF antibodies, anti-VEGF aptamer, gene therapy and protein kinase C inhibition. This article reviews the mechanism of action and rationale for anti-VEGF drugs in ARMD.
Description: 15 references.
URI: http://imsear.hellis.org/handle/123456789/72096
Appears in Collections:Indian Journal of Ophthalmology

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