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Title: Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy--pilot trial.
Authors: Shelat, B
Rao, B S
Vijaya, L
Revathi, B
Garg, D
Issue Date: 1-Jun-1996
Citation: Shelat B, Rao BS, Vijaya L, Revathi B, Garg D. Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy--pilot trial. Indian Journal of Ophthalmology. 1996 Jun; 44(2): 91-4
Abstract: To study the effect of 5-Fluorouracil (5-FU) in glaucoma filtration surgery, 13 eyes of 12 patients with glaucoma were subjected to trabeculectomy with intraoperative one minute exposure of 50 mg/ml 5-FU. The average age of patients was 36.42 +/- 18.78 years. Two of the patients had developed hypotony in the fellow eye following the use of Mitomycin C with trabeculectomy. The mean follow-up period was 9.54 +/- 5.17 weeks. Two patients developed a shallow anterior chamber with choroidals postoperatively which responded to conservative treatment. One patient developed an encysted bleb one month after surgery. Single one minute intraoperative exposure to 5-FU is a convenient and inexpensive method which appears to have no significant side effects. It may be a useful adjunctive treatment to optimise the results of glaucoma filtration surgery particularly in young and myopic patients. The long term effects, however, are not known.
Appears in Collections:Indian Journal of Ophthalmology

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