Please use this identifier to cite or link to this item: http://imsear.hellis.org/handle/123456789/70630
Title: Flavin nucleotides in human lens: regional distribution in brunescent cataracts.
Authors: Bhat, K S
Nayak, S
Issue Date: 28-Dec-1998
Citation: Bhat KS, Nayak S. Flavin nucleotides in human lens: regional distribution in brunescent cataracts. Indian Journal of Ophthalmology. 1998 Dec; 46(4): 233-7
Abstract: The biochemical mechanism(s) underlying brunescent cataracts remain unclear. Oxidative stress due to reactive oxygen species may have a role in the pigmentation process in eye lens. We have analysed human cataractous lenses for flavins by high-performance liquid chromatography (HPLC), since flavins are light sensitive and act as endogenous sensitizers generating reactive oxygen species in the eye. The most significant observation in this study is that higher levels of flavin nucleotides occur in brown lens compared to yellow lens. The concentration of flavin nucleotides (flavin monouncleotide, FMN + flavin adenine dinucleotide, FAD) was highest in the nuclear region of the lens followed by the cortical and capsule-epithelial regions. However, the ratio of FAD/FMN was lowest in the nuclear region of the lens followed by other regions. On the other hand, riboflavin was not detected in any of the lens (cataractous) regions. These results suggest that the observed increase in flavin nucleotides in the ocular tissue could contribute towards deepening of lens pigmentation.
URI: http://imsear.hellis.org/handle/123456789/70630
Appears in Collections:Indian Journal of Ophthalmology

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.