Please use this identifier to cite or link to this item:
|Title:||Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease.|
Khanna, V K
Seth, P K
|Citation:||Srivastava P, Saxena S, Khanna VK, Kumar D, Nath R, Seth PK. Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease. Indian Journal of Ophthalmology. 2000 Dec; 48(4): 307-9|
|Abstract:||BACKGROUND: Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease. METHODS: TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17). RESULTS: Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01). CONCLUSION: The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.|
|Appears in Collections:||Indian Journal of Ophthalmology|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.