Please use this identifier to cite or link to this item: http://imsear.hellis.org/handle/123456789/70505
Title: Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease.
Authors: Srivastava, P
Saxena, S
Khanna, V K
Kumar, D
Nath, R
Seth, P K
Issue Date: 9-Dec-2000
Citation: Srivastava P, Saxena S, Khanna VK, Kumar D, Nath R, Seth PK. Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease. Indian Journal of Ophthalmology. 2000 Dec; 48(4): 307-9
Abstract: BACKGROUND: Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease. METHODS: TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17). RESULTS: Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01). CONCLUSION: The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.
URI: http://imsear.hellis.org/handle/123456789/70505
Appears in Collections:Indian Journal of Ophthalmology

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